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Scientists finds a way to prevent cancer

In a new ground breaking study published in Nature communication the team of Alberta university identified the gene targets they could block more than 99 % of fatal cancer metastasis.
prevention of cancer
prevent cancer

According to Mr. Jown Lewis, the Alberta Cancer Foundation Frank and Carla Sojonky Chair in Prostate Cancer Research at the U of A and a member of the Cancer Research Institute of Northern Alberta (CRINA). Metastasis kills 90 per cent of all patients with cancer. With this study we have discovered 11 new ways to potentially end metastasis."
"We know that cancer, once it becomes metastatic, will continue to seed other parts of the body and the disease will progress and get worse because of that," said Lewis. "So I think if we can stop metastasis at any step of progression in cancer patients, we're going to have a significant effect on survival."


To visualize the growth and spread of cancer cells in real time. The researchers used a molecular tool called a knockout library to insert short hairpin RNA (shRNA) vectors into cancer cells. This shRNA bound to specific gene and stopped them from activating. Then these shRNA inserted in shell less avion embryos and observed as they formed clusters of cancer, identifying which ones showed properties of being non-metastatic.
"When we found compact colonies [of cancer], that meant all the steps to metastasis were blocked," said Konstantin Stoletov, lead author of the study and a research associate in the Lewis lab. "After that we could pull them out, query what the gene is, and then validate that the gene is actually responsible for metastasis."

This approach enabled the team to detect and identifies 11 genes that plays essential role in metastasis of cancer cells.
The next target of researchers is to progress to human trials over the next few years . They also expanding efforts to explore microRNA . microRNA may present even more stromger therapeutic targets to prevent metastasis.
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